The association between celiac disease and eosinophilic esophagitis

[jcc]

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Only registered and activated users can see links., Click Here To Register... 2013 May 30;13(1):96. [Epub ahead of print]
The association between celiac disease and eosinophilic esophagitis in children and adults.

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Abstract

BACKGROUND:

An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases.
METHODS:

All patients in a large Canadian city diagnosed with EoE or CD over a five-year period were identified. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated.
RESULTS:

Over the five-year study EoE was diagnosed in 421 patients and CD was diagnosed in 763 patients. The incidence of EoE ranged from 2.1 to 10.7 cases per 100,000 population. The incidence of CD ranged from 10.4 to 15.7 cases per 100,000 population. Among the EoE cohort, 83 (20%) cases of EoE and 245 (32%) cases of CD were diagnosed in pediatric patients. The incidence of EoE in the pediatric subpopulation ranged from 3.7 to 6.9 cases per 100,000 population. The incidence of CD in the pediatric subpopulation ranged from 9.5 to 22.7 cases per 100,000 population. The concomitant diagnosis of both EoE and CD was made in three patients, all of whom were pediatric males. The SIR for EoE in the CD cohort was 48.4 (95% CI = 9.73, 141.41) with a SIR for CD within the paediatric EoE cohort of 75.05 (95% CI = 15.08, 219.28).
CONCLUSIONS:

This study confirms the association between EoE and CD. However, this association may be limited to pediatrics where the risk of each condition is increased 50 to 75-fold in patients diagnosed with the alternative condition. The concomitant diagnosis of these conditions should be considered in pediatric patients with upper gastrointestinal symptoms.

[Razzle0]

Thanks for posting this. I don't think it would be limited to pediatric populations, but right now, that is where they are seeing the highest numbers of EE cases (my DH has EE and EG). Will be interesting to see if they do similar studies in the future and see if the numbers change...

Take care,

-Razzle
Gluten Sensitivity, GF since 2005.
Allergies, Lyme, Gastroparesis, many other issues...

[JudyLV]

My son had elevated eosinophils in his stomach and colon. He was quite sick at the time despite being gluten free. We started to work with a nutritionist and had some IgG food allergy tests run and he tested very positive to many foods (gluten, dairy, soy, eggs, legumes...). After removing these foods his symptoms calmed down. When I told the nurse in Dr. Fasano's group what had helped she said they do not fully support IgG testing but to keep doing what we are doing because "most of their eosinophil kids don't do so well".

This was back in 2005. I wonder if IgG testing is more accepted now. My son has been able to add eggs in baked goods back into his diet but he still can not tolerate the others.

--Judy

[nick's mom]

this reminds me that i want to get nick back in with his gi doc. this has been a constant problem for him (eoe) but he's always been negative for cd. he hasn't been to see them for a while so we should head back and see how things look now.

[annelb]

Judy, I doubt that conventional medicine docs are doing IgG tests for food sensitivity.

Luanne, I hope Nick decides to see if getting rid of gluten and other inflammatory foods might help him feel better.
Anne