Is it possible that a GF diet for the children without CD would also show a kidney protective effect?
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Pediatr Diabetes. 2013 Jun 14. doi: 10.1111/pedi.12028. [Epub ahead of print]
Coeliac disease, gluten-free diet and the development and progression of albuminuria in children with type 1 diabetes.
Gopee E, van den Oever EL, Cameron F, Thomas MC.
Source
Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, Victoria, Australia.
Abstract
OBJECTIVES:
Although a diagnosis of coeliac disease (CD) may be confronting to children with type 1 diabetes and their families, we hypothesize that children with CD have lower urinary albumin excretion, a marker of renal dysfunction.
RESEARCH DESIGN:
Twenty-four children with type 1 diabetes and biopsy-proven CD, on a gluten-free diet for at least 1 yr, were recruited from a single paediatric diabetes clinic alongside 55 children with type 1 diabetes but without CD matched for age, gender, duration of diabetes, and glycaemic control.
RESULTS:
Despite comparable diabetes exposure, glycaemic control and nutritional status, children with type 1 diabetes and CD had a lower urinary albumin creatinine ratio than in diabetic subjects without CD (0.9 ± 0.3 mg/mmol vs. 1.6 ± 0.3 mg/mmol; p = 0.01). Participants with CD also showed slower progression in albuminuria over 5-yr of follow-up while a small but significant increase was observed in the children with diabetes alone (1.6 ± 0.3 mg/mmol; follow-up 2.4 ± 0.5 mg/mmol; p = 0.02).
CONCLUSIONS:
As urinary albumin excretion is continuously associated with the risk of kidney disease, it is possible to speculate that CD or its management confers a degree of renoprotection. Larger studies are required to test this hypothesis.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PMID:
23763501
[PubMed - as supplied by publisher]
Coeliac disease, gluten-free diet and the development and progression of albuminuria in children with type 1 diabetes.
Gopee E, van den Oever EL, Cameron F, Thomas MC.
Source
Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, Victoria, Australia.
Abstract
OBJECTIVES:
Although a diagnosis of coeliac disease (CD) may be confronting to children with type 1 diabetes and their families, we hypothesize that children with CD have lower urinary albumin excretion, a marker of renal dysfunction.
RESEARCH DESIGN:
Twenty-four children with type 1 diabetes and biopsy-proven CD, on a gluten-free diet for at least 1 yr, were recruited from a single paediatric diabetes clinic alongside 55 children with type 1 diabetes but without CD matched for age, gender, duration of diabetes, and glycaemic control.
RESULTS:
Despite comparable diabetes exposure, glycaemic control and nutritional status, children with type 1 diabetes and CD had a lower urinary albumin creatinine ratio than in diabetic subjects without CD (0.9 ± 0.3 mg/mmol vs. 1.6 ± 0.3 mg/mmol; p = 0.01). Participants with CD also showed slower progression in albuminuria over 5-yr of follow-up while a small but significant increase was observed in the children with diabetes alone (1.6 ± 0.3 mg/mmol; follow-up 2.4 ± 0.5 mg/mmol; p = 0.02).
CONCLUSIONS:
As urinary albumin excretion is continuously associated with the risk of kidney disease, it is possible to speculate that CD or its management confers a degree of renoprotection. Larger studies are required to test this hypothesis.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PMID:
23763501
[PubMed - as supplied by publisher]