Prion seeding activity and infectivity in skin samples from patients with sCJD

[flatfish]

WEDNESDAY, NOVEMBER 22, 2017

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease

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kind regards, terry

[flatfish]

Although sCJD patient skin contained ~103- to 105-fold lower prion seeding activity than did sCJD patient brain tissue, all 12 mice from two transgenic mouse lines inoculated with sCJD skin homogenates from two sCJD patients succumbed to prion disease within 564 days after inoculation. ...

for something to be 103 to 105 fold lower prion seeding, yet still be 100% fatal in all test subjects, very disturbing imo...terry