Abstract of study on low dose naltrexone

[Lazarus]

Clin Rheumatol. 2014 Feb 15. [Epub ahead of print]
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.
Younger J, Parkitny L, McLain D.
Author information

Abstract
Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone's better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.
PMID: 24526250 [PubMed - as supplied by publisher]
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[Jeanie Z]

:) Hi everyone. Linda I have been on 4.5 mg of LDN nightly for 14 years. I wish all MSers would try it.

A few MSers I know who are on LDN had symptom improvement, some of several symptoms and as long as they have stayed on LDN the symptoms did not come back. I had no symptom inprovement but I have not progressed any further than I was when I began it. That is good enough for me as I had frequent new symptoms before LDN and none since using it. Jeanie :)

Only registered and activated users can see links., Click Here To Register...

[Cherie]

I have been on it since August. Went off for a couple of weeks when I was trying to figure if it was worsening sleep disorder, then back on until three weeks ago. I cannot saw that I say any improvement or stabilization on it and feel no differently off it. That said, I am improving as far as symptoms left over from last March's relapse. I attribute that to being back on an Interferon since October.

[SalpalSally]

I'm only on LDN for 11 yrs now, so I'm sure, that I feel better because of the LDN!!

And thanks Jeanie, that info is so good to know.

[SalpalSally]

Does anyone know, what ever happened to LarryLDN?
Haven't seen that little stinker for years.

[agate]

Does anyone know, what ever happened to LarryLDN?
Haven't seen that little stinker for years.

He's logged in just now. I happened to notice, and then I saw your post.

Maybe now that he's been revealed, he'll say a few words. Many people here must remember him.

[LarryLDN]

Does anyone know, what ever happened to LarryLDN?
Haven't seen that little stinker for years.

8 years? 4 years?

Life as I knew it ended 1st 2/06, I had my last cigarette 2 months later, 4/26/2006. 2 years later my career ended, on the 5th anniversary of LDN, 4/17/08. 2 months later, the divorce was decreed. After an unbelievably awesome 2009 (not medically, in spite of), I ended up in Florida for 6 weeks ending with buying a condo, to be near my dad since LDN saved his life in 3/2007. I moved to Florida 3/10.



As for just the LDN, after finding out in 2007 that all my food allergies disappeared (from 1972 & 2003, pre-LDN), I had the tests redone in 2009 to confirm. After moving to Florida, the following year, 5/11, I had an allergist run the tests again. Still 0 food allergies. Chocolate was the biggie; to be able to eat chocolate again is amazing.

MRI's as noted in Only registered and activated users can see links., Click Here To Register... I had one in 4/2007 showing no progression, but still the same bad lesion load from 2002-3, and then another in 4/2008 pretty much confirming the stability but clearly MS. AND.... 5 years later.... I had an MRI in 7/2013 that "except for showing age" they see NO Progression from previous MRI.




As far as Symptoms, my lesion load hasn't changed, hasn't Improved at all, therefore I still am Suffering with the same issues from the initial improvements.


On LDN we can have an awesomely running immune system, whatever else you may have going on, it may have nothing to o with. NO Colds or FLU or ALLERGIES, much improved bladder vs pre-LDN (still a slave to it a lot), and still the hair & nails growth hasn't slowed any. I started shaving my head 4/09 and still do.

Last year I had some foot pain & they also thought a brace for my left foot could help with the MS... It does.. but it also helps with the foot pain. So I can walk better with it, plus the foot pain is also alleviated.



Oh, still on 3.0



There ya go... still kicking

[SalpalSally]

Hello Larry, come on in. How are you doing?

[agate]

Well, at least we know he's still among the survivors, and that's good.

[LarryLDN]

Survivors. Yep

[Cherie]

Sounds like a difficult few years that had at least one bright spot in them. Good to see you again.

[SalpalSally]

NiCe to hear from you Larry. Living in Florida is sure different than living in New York.
How are you with the humidity down there? How is your Dad and Kids. They must be
grown by now!!

[Robwill57]

didn't help me

I'm happy for all of you that LDN helped, but it didn't do anything for me. Except keep me awake at night. Started at 1.5 and increased to 4.5 in 4 months time. I really hoped it would help.

[agate]

Welcome back, Robwill, and thanks for sharing your LDN experience.

I notice in your earlier post that you took Copaxone for 11 years. You're clearly very determined to do whatever you can to fight MS off.

If you don't mind a question, are you taking any MS drugs at this point?

[LarryLDN]

Looks like this is my only post here, 3+ years ago... nice to see this forum still here. I'm still around, mostly twitter related... plus I bought an RV 12/13 & have been traveling around the country ALONE... Me, My MS, My LDN & My RV. Still taking LDN 3MG every day.