Fascinating that it only helped PwMS for the first 3 monthly courses only:
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Mult Scler. 2015 Nov 12. pii: 1352458515617248. [Epub ahead of print]
Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica.
Yamasaki R1, Matsu****a T1, Fukazawa T2, Yokoyama K3, Fujihara K4, Ogino M5, Yokota T6, Miyamoto K7, Niino M8, Nomura K9, Tomioka R10, Tanaka M11, Kawachi I12, Ohashi T13, Kaida KI14, Matsui M15, Nakatsuji Y16, Ochi H17, Fukaura H18, Kanda T19, Nagaishi A20, Togo K21, Mizusawa H6, Murai H22, Kira JI22.
Abstract
BACKGROUND:
No large-scale studies have compared the efficacy of intravenous methylprednisolone pulse therapy (IVMP) for multiple sclerosis (MS) and neuromyelitis optica (NMO).
OBJECTIVE:
To explain differences in treatment responses of MS and NMO patients to IVMP.
METHODS:
Changes in neurological symptoms/signs and Expanded Disability Status Scale (EDSS) scores before and within 1 week of IVMP completion were obtained in 2010 at 28 institutions, and retrospectively collated from 271 MS (478 courses) and 73 NMO (118 courses) cases.
RESULTS:
In MS patients, decreased EDSS score was significant after the first (-0.8 ± 0.9), second (-0.7 ± 0.9), and third (-0.7 ± 0.8) courses (p < 0.05), but not after the fourth (-0.3 ± 0.7) and fifth (-0.5 ± 0.6). However, decreased EDSS score was only significant after the first course (-0.5 ± 1.5, p < 0.05) in NMO patients. EDSS score was significantly decreased in MS compared with NMO patients at the first course (p < 0.05), but not thereafter. Model analysis for EDSS score improvement at the first course, adjusting for covariates, showed significantly greater decreases in MS compared with NMO patients (p < 0.05).
CONCLUSION:
IVMP is effective in MS from the first to third courses, and in NMO at the first course. Additionally, IVMP is more efficacious in MS than NMO patients, even at the first course
Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica.
Yamasaki R1, Matsu****a T1, Fukazawa T2, Yokoyama K3, Fujihara K4, Ogino M5, Yokota T6, Miyamoto K7, Niino M8, Nomura K9, Tomioka R10, Tanaka M11, Kawachi I12, Ohashi T13, Kaida KI14, Matsui M15, Nakatsuji Y16, Ochi H17, Fukaura H18, Kanda T19, Nagaishi A20, Togo K21, Mizusawa H6, Murai H22, Kira JI22.
Abstract
BACKGROUND:
No large-scale studies have compared the efficacy of intravenous methylprednisolone pulse therapy (IVMP) for multiple sclerosis (MS) and neuromyelitis optica (NMO).
OBJECTIVE:
To explain differences in treatment responses of MS and NMO patients to IVMP.
METHODS:
Changes in neurological symptoms/signs and Expanded Disability Status Scale (EDSS) scores before and within 1 week of IVMP completion were obtained in 2010 at 28 institutions, and retrospectively collated from 271 MS (478 courses) and 73 NMO (118 courses) cases.
RESULTS:
In MS patients, decreased EDSS score was significant after the first (-0.8 ± 0.9), second (-0.7 ± 0.9), and third (-0.7 ± 0.8) courses (p < 0.05), but not after the fourth (-0.3 ± 0.7) and fifth (-0.5 ± 0.6). However, decreased EDSS score was only significant after the first course (-0.5 ± 1.5, p < 0.05) in NMO patients. EDSS score was significantly decreased in MS compared with NMO patients at the first course (p < 0.05), but not thereafter. Model analysis for EDSS score improvement at the first course, adjusting for covariates, showed significantly greater decreases in MS compared with NMO patients (p < 0.05).
CONCLUSION:
IVMP is effective in MS from the first to third courses, and in NMO at the first course. Additionally, IVMP is more efficacious in MS than NMO patients, even at the first course
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