Tecfidera may cause liver injury

[SuzE-Q]

Important to regularly check liver enzymes if on Tec?

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Mult Scler.
2017 Jan 1

Liver injury associated with dimethyl fumarate in multiple sclerosis patients.

Muņoz MA1, Kulick CG1, Kortepeter CM1, Levin RL1, Avigan MI1.

Abstract
BACKGROUND:
In pre-approval trials, there was an increased incidence of mild, transient elevations of liver aminotransferases in study subjects treated with dimethyl fumarate (DMF).

OBJECTIVE/METHODS:
To evaluate post-marketing cases of drug-induced liver injury associated with DMF.

RESULTS:
We identified 14 post-marketing cases of clinically significant liver injury. Findings included newly elevated serum liver aminotransferase and bilirubin levels that developed as early as a few days after the first dose of DMF. The pattern of liver injury was primarily hepatocellular. No cases resulted in liver failure.

CONCLUSION:
Health professionals should be alerted to possible serious liver injury in patients receiving DMF.

[Cat Dancer]

yes, I get blood tests once a year just for this reason. When I started, it was 4 times a year. No issues, yet...

[SuzE-Q]

Good to hear, Cat. It's not the first DMD to risk liver injury. Any med metabolized there risks possible side effect there.

Glad your doc monitors you well!