I don't know if the word "intriguing" is the one I'd use, but concerning possibility for Tysabri-treated persons to develop PML from close contact with another with JC virus who first develops PML:
Mult Scler. 2017 Feb;23(2):300-303. doi: 10.1177/1352458516670734.
Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence.
Bacchetta F1, Mathias A1, Schluep M1, Du Pasquier R1.
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Mult Scler. 2017 Feb;23(2):300-303. doi: 10.1177/1352458516670734.
Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence.
Bacchetta F1, Mathias A1, Schluep M1, Du Pasquier R1.
BACKGROUND:
Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML).
OBJECTIVE:
We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1.
CONCLUSION:
The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.
Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML).
OBJECTIVE:
We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1.
CONCLUSION:
The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.
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