Did you know that Humira, which is another monoclonal antibody treatment often used for the autoimmune diseases Rheumatoid arthritis and Crohn's disease, has been known in more than a few patients to CAUSE MS?!?? At least temporarily?
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Clin Rheumatol. 2013 Feb;32(2):271-5.
New-onset multiple sclerosis associated with adalimumab treatment in rheumatoid arthritis: a case report and literature review.
Matsumoto T1, Nakamura I, Miura A, Momoyama G, Ito K.
Abstract
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Clin Rheumatol. 2013 Feb;32(2):271-5.
New-onset multiple sclerosis associated with adalimumab treatment in rheumatoid arthritis: a case report and literature review.
Matsumoto T1, Nakamura I, Miura A, Momoyama G, Ito K.
Abstract
Tumor necrosis factor (TNF) antagonists have brought about a significant advancement in treatment for autoimmune diseases such as rheumatoid arthritis (RA) and Crohn's disease; however, they are accompanied with a risk of severe adverse effects.
We report the case of a 68-year-old female with a 33-year history of RA that developed multiple sclerosis (MS) during adalimumab (ADM) treatment at 22 months after the initial administration.
Her first neurological symptom was mild dizziness, which progressed to severe dizziness with gait disturbance within 2 weeks. Fortunately, when she had this neurological disorder, ADM treatment was being transiently stopped because she was in the perioperative period.
Repeated magnetic resonance imaging examinations revealed multiple demyelinating lesions in her brain, leading to the diagnosis of MS. The patient completely recovered spontaneously from the symptoms in several days.
A review of the literature revealed another 15 cases of MS associated with anti-TNF-α treatment, emphasizing the importance of detecting neurological symptoms and discontinuing the anti-TNF-α therapy.
We report the case of a 68-year-old female with a 33-year history of RA that developed multiple sclerosis (MS) during adalimumab (ADM) treatment at 22 months after the initial administration.
Her first neurological symptom was mild dizziness, which progressed to severe dizziness with gait disturbance within 2 weeks. Fortunately, when she had this neurological disorder, ADM treatment was being transiently stopped because she was in the perioperative period.
Repeated magnetic resonance imaging examinations revealed multiple demyelinating lesions in her brain, leading to the diagnosis of MS. The patient completely recovered spontaneously from the symptoms in several days.
A review of the literature revealed another 15 cases of MS associated with anti-TNF-α treatment, emphasizing the importance of detecting neurological symptoms and discontinuing the anti-TNF-α therapy.
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