So, if you google the question about whether MS is a metabolic disease you will find lots of NIH current articles.
Here is a bit I Copied:
Multiple Sclerosis Is Not a Disease of the Immune System
Angelique P Corthals 1
Affiliations expand
PMID: 22384749 DOI: 10.1086/662453
Abstract
Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations. Despite great advances in documenting the cell and molecular mechanisms underlying MS pathophysiology, the autoimmunity framework has also been unable to develop a comprehensive explanation of the etiology of the disease. I propose a new framework for understanding MS as a dysfunction of the metabolism of lipids.
Specifically, the homeostasis of lipid metabolism collapses during acute-phase inflammatory response triggered by a pathogen, trauma, or stress, starting a feedback loop of increased oxidative stress, inflammatory response, and proliferation of cytoxic foam cells that cross the blood brain barrier and both catabolize myelin and prevent remyelination. Understanding MS as a chronic metabolic disorder illuminates four aspects of disease onset and progression: 1) its pathophysiology; 2) genetic susceptibility; 3) environmental and pathogen triggers; and 4) the skewed sex ratio of patients. It also suggests new avenues for treatment.
Similar articles
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis
V Ferret-Sena et al. Int J Mol Sci 19 (6). 2018. PMID 29865151. - Review
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic …
The Role of Gut Microbiome and Associated Metabolome in the Regulation of Neuroinflammation in Multiple Sclerosis and Its Implications in Attenuating Chronic Inflammation in Other Inflammatory and Autoimmune Disorders
N Dopkins et al. Immunology 154 (2), 178-185. Jun 2018. PMID 29392733. - Review
The importance of the gut microbiome in the regulation of non-infectious diseases has earned unprecedented interest from biomedical researchers. Widespread use of next-ge …
Lipids at the Cross-road of Autoimmunity in Multiple Sclerosis
M Reale et al. Curr Med Chem 24 (2), 176-192. 2017. PMID 27881065. - Review
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS) characterized by demyelination and neurodegeneration, driven by a Th …
Molecular Genetic and Epigenetic Basis of Multiple Sclerosis
Z Hojati. Adv Exp Med Biol 958, 65-90. 2017. PMID 28093709. - Review
Multiple Sclerosis (MS) is a chronic immune-mediated disease of spinal cord and brain. The initial event in MS occurs when activated CD4+ T cells in periphery …
Signaling Pathways and Therapeutic Perspectives Related to Environmental Factors Associated With Multiple Sclerosis
S Tiwari et al. J Neurosci Res 96 (12), 1831-1846. Dec 2018. PMID 30204260. - Review
Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D defic …
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Here is a bit I Copied:
Multiple Sclerosis Is Not a Disease of the Immune System
Angelique P Corthals 1
Affiliations expand
PMID: 22384749 DOI: 10.1086/662453
Abstract
Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations. Despite great advances in documenting the cell and molecular mechanisms underlying MS pathophysiology, the autoimmunity framework has also been unable to develop a comprehensive explanation of the etiology of the disease. I propose a new framework for understanding MS as a dysfunction of the metabolism of lipids.
Specifically, the homeostasis of lipid metabolism collapses during acute-phase inflammatory response triggered by a pathogen, trauma, or stress, starting a feedback loop of increased oxidative stress, inflammatory response, and proliferation of cytoxic foam cells that cross the blood brain barrier and both catabolize myelin and prevent remyelination. Understanding MS as a chronic metabolic disorder illuminates four aspects of disease onset and progression: 1) its pathophysiology; 2) genetic susceptibility; 3) environmental and pathogen triggers; and 4) the skewed sex ratio of patients. It also suggests new avenues for treatment.
Similar articles
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis
V Ferret-Sena et al. Int J Mol Sci 19 (6). 2018. PMID 29865151. - Review
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic …
The Role of Gut Microbiome and Associated Metabolome in the Regulation of Neuroinflammation in Multiple Sclerosis and Its Implications in Attenuating Chronic Inflammation in Other Inflammatory and Autoimmune Disorders
N Dopkins et al. Immunology 154 (2), 178-185. Jun 2018. PMID 29392733. - Review
The importance of the gut microbiome in the regulation of non-infectious diseases has earned unprecedented interest from biomedical researchers. Widespread use of next-ge …
Lipids at the Cross-road of Autoimmunity in Multiple Sclerosis
M Reale et al. Curr Med Chem 24 (2), 176-192. 2017. PMID 27881065. - Review
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS) characterized by demyelination and neurodegeneration, driven by a Th …
Molecular Genetic and Epigenetic Basis of Multiple Sclerosis
Z Hojati. Adv Exp Med Biol 958, 65-90. 2017. PMID 28093709. - Review
Multiple Sclerosis (MS) is a chronic immune-mediated disease of spinal cord and brain. The initial event in MS occurs when activated CD4+ T cells in periphery …
Signaling Pathways and Therapeutic Perspectives Related to Environmental Factors Associated With Multiple Sclerosis
S Tiwari et al. J Neurosci Res 96 (12), 1831-1846. Dec 2018. PMID 30204260. - Review
Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D defic …
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