Osteoporosis

[annelb]

Got another bone scan and when compared to the one 4 yrs before, there had been bone loss putting me into the osteoporosis categore :(

I am refusing to go on the prescription medications. I really don't trust them.

I really think that this loss is related to continuing inflammation in my body. I still have an elevated hsCRP and my ferritin is elevated but the other iron tests show this is not iron overload. This can happen from infection and inflammation. Infection - I am positive for Lyme Disease and Rocky Mtn Spotted Fever. There is also a possible link between insulin resistance and osteoporosis. I know I have this too.

Plan is to get a fasting insulin and blood glucose and check HOMA. Only registered and activated users can see links., Click Here To Register...

Also do a NTX test to see rate of bone loss. Only registered and activated users can see links., Click Here To Register...

I am then going to start on Ostera. Only registered and activated users can see links., Click Here To Register... I heard about this from the Dr. Hoffman radio show, Health Talk. I listen on podcast. He says he has seen good results with this. He is also on FB.

Another consideration is Cyplexinol Only registered and activated users can see links., Click Here To Register...

My integrative doc also wants me to start using gelatin by Great Lakes - I have to find out which one.

This is another big push to start an exercise program.
Anne

[canoe]

Anne,

Sorry to hear that you have progressed to the osteoporotic range. Dr. Susan Ott has a very helpful site Only registered and activated users can see links., Click Here To Register...

I was dx with osteoporosis a long time ago and took the bisphosphonates for many years. When I was diagnosed with the gluten intolerance and celiac issues, once I went gluten free, my bone density improved
considerably. I went from osteopenic range to nearly normal once I quit the gluten. Inasmuch as I had not changed medications I am reasonably certain that better absorption of nutrients made a big difference in my bone
density.

My Gynecologist also had tested me for testosterone levels, and since mine was prepubescent level, she added topical testosterone in a very small amount.

In 2009 I stopped the bisphosphonate w/o checking with the doctor because I wanted to be off because of a needed tooth implant. The doctor was not happy with me. My follow up Dexa Scan's have shown that my bone density remains
stable w/o the medication.

Exercise should help. Good luck with getting this additional problem under control.

Hugs, Marilyn

[annelb]

Thanks Marilyn, I will check out the link. Currently I am waiting for test results. My integrative doc did and NTX which is a urine test to see how fast I am losing bone. She also ordered a insulin and blood sugar to plug into a HOMA calculator to see how much insulin resistance I have.

I was thinking about taking Ostera but my PCP is concerned as it has K1 and the possible association of blood clots. Well, I found some good supportive papers that K1 can be good for the blood vessels. I certainly get a bunch of it in my diet as I eat lots of dark leafy greens. My concern is the berberine. That has antibiotic action and could mess up gut flora. It is also a DPP-4 inhibitor and drugs in that class have been associated with pancreatic problems. So I don't think that is a good option either.

The only change so far is my integrative doc wants me to add in geletin. Only registered and activated users can see links., Click Here To Register...

Anne

[NancyM]

Anne, isn't it K2 (especially, MK7) that is supposed to be good for bones? Here's an article about it from Dr. Davis: Only registered and activated users can see links., Click Here To Register...

I'm a bit leary of K1 myself since I have a genetic predisposition to clotting, but I believe K2 doesn't have that issue.

[canoe]

Anne,

Thanks for the update. It sounds like she did a very comprehensive work up.
Hope that you do not have a lot of insulin resistance.

Nancy, I did add K2 to my supplements and it seems to me that there was a slight increase in bone density after adding it. My 23 and me results that I have an increase risk of clotting also. Wasn't happy about that, but at least I know and can watch for possible problems.

Marilyn

[NancyM]

Do you have the Factor V Leiden gene? My brother is homozygous for it, but I'm only hetrozygous (yay!). Still, I have a 27% risk of having DVT.

[annelb]

I do take K2. I do have insulin resistance that I am trying to control with a very low carb diet. I am wondering if that is still playing a part as my blood sugars are not perfect and in spite of eating few carbs my triglycerides are still a little over 100.

I don't think I have Factor V Leiden, but I have never been tested.

[NancyM]

Have you tried cutting down on protein, Anne? I may have asked you that before. I find that my blood sugar can drop 20-30 points if I keep my protein in the 60-70g per day range, keep total carbs to 50g or less, and (carbs - fiber) to 20 or less. I seem to be very good at converting protein to glucose or else eating too much protein makes me very insulin resistant.

[canoe]

Nancy,

I do have Factor V, but not sure if it is the Leiden and my report says that I have 35.4% increased risk for DVT vs normal population with 9.7%. I do not know if I am hetero or homozygous for this. I am still working with the 23 and me report and have not
uploaded to Promethease, so I am not clear on this.

I have one gene near the ABO region and the report states that this increasing clotting in persons who are not O blood type. My blood type is B/O so I do not know if the O part offsets the increased risk.

Marilyn

[NancyM]

They've changed around the reports a bit.

Mine says (under health risks): Venous Thromboembolism 26.9%

Then under the Technical report it says:
Gene or region: F5
SNP: rs6025
I am: rs6025 CT European: 4.67
+++ This is the Factor V gene, which is the Leiden Factor V mutation I think. Only certain people with roots in a certain city in Germany have it. I'm not homozygous for that gene, but my brother is.

Gene or region: F2
SNP: i3002432
I am: GG risk 1.0 (No extra risk)

Gene or region: ABO
SNP: rs505922
rs505922 TT European: 0.73
This one reduces my risk a little.

Oh wow... just saw the Telomere length study.

[canoe]

Nancy

Mine under Technical Report
Gene F5
SNP rs6025
Genotype CT European 4.67

Gene or region F2
SNP: i3002432
Allele GG European 1.0

Gene ABO
SNP: rs505922
Genotype CT
Odds, European 1.09

The fact that I am CT and not TT like you on the ABO area gives me a little more risk.

Can I assume that I am heterozygous based on the above?

Marilyn

[annelb]

What telomere study? Or are you saying your telomere length was good? bad? Does 23 and me test telomere length?
Anne

[NancyM]

The Genotype can be either C, T, G or A. If they're the same: CC, TT, GG, AA that means you're homozygous for that gene which means more likely to have a stronger version of whatever that gene does. CT, CG, etc is heterozygous.

You get one of those letters from mom, and one from dad. :)

You're homozygous for the second SNP.

[NancyM]

They have a report on your genes and their effect on your telomere length. It is under Traits/Biological Aging

Mine says:
rs10936599 CT Shorter telomeres on average, equivalent to those of a person 3.91 years older.
rs2736100 AC Typical telomere length on average.
rs9420907 AC Longer telomeres on average, equivalent to those of a person 2.76 years younger.
rs755017 AG Longer telomeres on average, equivalent to those of a person 2.47 years younger.
rs11100479 CT Shorter telomeres on average, equivalent to those of a person 2.99 years older.
rs10165485 TT Typical telomere length on average.
================
1.67 years old... ? Bummer!

You can see that if you had all the right genes you might actually have really, really long telomeres and be 18 years younger biologically.

[canoe]

Anne, Yes, they do test for the telomere length.

They test for a lot of traits, including muscle fiber, ie. I am a sprinter type because I have 2 copies of Alpha-actinin 3 which is the fast twitch muscle fiber.

I am a slow metabolizer of caffeine, and resistant to one form of the Noro Virus.

There is so much information to go through but very interesting.

Marilyn