What guts!

[SuzE-Q]

I wouldn't have wanted to be the scientists involved in this research...

What a crazy world if fecal transplants ends up being our cure.

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Sci Rep.
2016 Jun 27

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.

Chen J1, Chia N2,3, Kalari KR1, Yao JZ2, Novotna M4,5, Soldan MM4, Luckey DH6, Marietta EV7, Jeraldo PR2, Chen X1, Weinshenker BG4, Rodriguez M4,6, Kantarci OH4, Nelson H2, Murray JA6,7, Mangalam AK6,8.

Abstract
Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS.

Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36).

Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls.

We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis [= microbial imbalance or maladaptation on or inside the body] and further study is needed to better understand their role in the etiopathogenesis of MS

[SalpalSally]

OMG!!!!!!!

[Howie]

You can give Sally a double dose because I pass on that one!

[Frog42]

No thanks. Ewwww.

[agate]

I hope the researchers will give up on this idea soon.

[Howie]

But what's sad, some group of nobody's made a living from the money being spent for this "research". The whole concept is full of holes (no pun intended) I'm surprised they talked someone into financing it. They would make a heck of a used car salesman!

[Catdancer]

Actually this is not so crazy. I've been reading several different wound articles about this, and find it plausible. Yes, there's an ick factor, but if it works, I'd do it!

[stillstANNding]

I know someone who had a fecal transplant because she almost died from CDiff. After many weeks of IV antibiotics she needed to repopulate her bowel. They'd like the donor to be from your household. She lived alone and so they contacted her mother.

Fortunately it was successful.

Now please do not reply so we don't have to look at this topic at breakfast tomorrow.
ANN

[Howie]

How about having dinner? We're having steak on a stick, black eyed peas, and brownies for dessert.

[Virginia]

Howie, really you are just too much!!!!

[Sunshine]

Whoa! This is fascinating! I wonder if that's one rEason IVIG can be beneficial. Maybe the antibodies alter the gut environment...I would do this in a hearbeat.

[Virginia]

I saw something on TV where Doctors were discussing the fact that in countries where people have more parasitic worms there is less autoimmune diseases, such as lupus and multiple sclerosis. That is not to say we should go out and eat worms. However, it is interesting.

[agate]

There are some MS treatments involving worms. If you do a Google search on "helminths and multiple sclerosis," you'll probably find out more. For instance:

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Wasn't there a discussion of this here a while back too?

[SalpalSally]

With all of the unusual ingredients in our meds , nothing would surprise me!

[SuzE-Q]

No, Howie, fecal transplants isn't as farfetched an idea as you might think! This is actually quite mainstream, at least as far as c.diff infections as ANN mentioned. It's been looked at for a # of other different illnesses as well at the moment.

BBS, I believe the working theory about why IVIG may work for some MSer's is that it overwhelms the immune system by an external influx of antibodies causing it to plummet.